Effect of POR knockout on hypoxic prodrug activation
نویسندگان
چکیده
Background: NADPH:cytochrome P450 oxidoreductase (POR) catalyses one-electron reduction of hypoxia-activated prodrugs (HAP). Results: Knockout of POR in tumour cells inhibited activation of some HAP (e.g. 5nitroquinoline SN24349) but not others (e.g. PR104A, TH-302). Conclusion: POR at endogenous levels plays a variable role in HAP activation. Significance: POR expression alone is not a sufficient predictive biomarker for activation of most HAP.
منابع مشابه
FSL-61 is a 6-nitroquinolone fluorogenic probe for one-electron reductases in hypoxic cells.
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